The research topic of Ueno's lab in the past decade has been to define the immune mechanisms associated with antibody responses in humans. In particular, he has focused on the biology of T follicular helper (TFH) cells in humans, a CD4+ T cell subset specialized for the provision of help for antibody responses. TFH response needs regulation, as insufficient and excessive responses cause health problems: Insufficient TFH response causes failure in the development of antibody responses for example in response to vaccination, while excessive TFH response causes autoimmunity by promoting the generation of autoantibodies. His research on human Tfh cells has two major goals: To define the cellular and molecular mechanisms to generate durable and high affinity antibody responses after infection and vaccination, and to understand the disease mechanisms in autoantibody-mediated autoimmune diseases.
Anti-Tumor Therapy, Autoimmunity, B Cells, Cellular Differentiation, Cellular Immunity, Cytokines, Dendritic Cells, Immunology, Infectious Disease, Inflammation, Influenza Virus, Lupus Nephritis, Lymphocytes, Macrophage, Molecular Biology, Signal Transduction, Systems Biology, T Cells
Multi-Disciplinary Training Areas
Clinical Research Education Program [CLR], Immunology [IMM], Microbiology [MIC]